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Wednesday
Apr202016

Monsanto Chemical May Lead to Weight Gain

A New study by researchers at the University of Georgia says that exposure to a chemical manufactured by Monsanto called benzyl butyl phthalate may cause cells store more fat. 

"Phthalate exposure can be closely associated with the rise of different types of disease development," said the study's lead author Lei Yin, an assistant research scientist in the UGA College of Public Health's department of environmental health science.

Because levels of phthalates were found in human fluids in previous studies, the researchers wanted to see if a specific phthalate, benzyl butyl phthalate, or BBP, manufactured by Monsanto (source) had an effect on the accumulation of fat in cells. Their findings were published in the journal Toxicology in Vitro.

Benzyl butyl phthalate is used in the manufacturing of vinyl tile and can also be found as a plasticizer in polyvinyl chloride (PVC). It is used in the manufacturing of conveyor belts, carpet, weather stripping and more. When BBP is added during the manufacturing of a product, it is not bound to the final product.  However, through the use and disposal of the product, BBP can be released into the environment.  BBP can be deposited on and taken up by crops for human and livestock consumption, resulting in its entry into the food chain. The biggest source of exposure to BBP is through foods. (Source)

The researchers used mouse cells to analyze how exposure to BBP affected the way oils and fats, known as lipids, accumulated within the cells.

"Obesity is one of the big issues in humans now, and of course genetic components can contribute to the development of obesity," said study co-author Xiaozhong "John" Yu, an assistant professor of environmental health science. "However, environmental exposure may also contribute to obesity."

Some phthalates have proven to cause reproductive toxicity at high levels of exposure, but the link between low-level exposure and BBP hadn't yet been thoroughly explored, Yin explained.

"It could be that some chemicals at a very low dose and over a long period time, which is known as chronic exposure, can cause more harmful diseases or effects," she said.

The researchers quantified lipid droplet accumulation using traditional staining approaches, in which the cells are stained and therefore can be visually assessed under a microscope, and a newer approach called cellomics high-content analysis. This high-content screening uses "image processing algorithms, computer machine learning and can measure the multiple parameters in a fast and objective way," Yin said.

The results of BBP's effects were compared with bisphenol A, or BPA, an environmental endocrine disruptor that is known for its role in adipogenesis, or how fat cells develop.

BBP caused a response in the cells that is similar to BPA: Both chemicals prompt the accumulation of lipid droplets. However, the droplets from BBP-treated cells were larger, something that suggests BBP exposure may lead to obesity.

Although the findings cannot be directly generalized to the human population--Yu notes the cells used were mouse cells and a "human is not a big mouse"--they do give an indication of a possible link between exposure to BBP and obesity, something that could affect human health.

Calling obesity research a very exciting area to be studying, Yin said she would like to explore the relationships between other environmental chemicals and obesity in future studies. She is also interested in learning if certain plant-based chemicals could counterbalance the negative effects of exposure to more harmful chemicals.

(Source

Reader Comments (1)

New but great info

Sat, July 22, 2017 | Unregistered CommenterJean

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